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Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2016 Aug 26; Vol. 17 (9). Date of Electronic Publication: 2016 Aug 26. - Publication Year :
- 2016
-
Abstract
- Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Hepatocytes drug effects
Hepatocytes metabolism
Humans
Oxidative Stress drug effects
Reactive Oxygen Species metabolism
Antioxidants chemistry
Antioxidants pharmacology
Emulsions chemistry
Hydrogen Peroxide pharmacology
Nanostructures chemistry
Saponins chemistry
Vitamin A chemistry
Vitamin A pharmacology
Vitamin E chemistry
Vitamin E pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27571071
- Full Text :
- https://doi.org/10.3390/ijms17091406