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[Unpreserved latanoprost in the treatment of open-angle glaucoma and ocular hypertension. A multicenter, randomized, controlled study].
- Source :
-
Journal francais d'ophtalmologie [J Fr Ophtalmol] 2016 Sep; Vol. 39 (7), pp. 622-30. Date of Electronic Publication: 2016 Aug 25. - Publication Year :
- 2016
-
Abstract
- Objectives: To evaluate the safety and efficacy of unpreserved latanoprost eye drops (UNL) in comparison with preserved latanoprost eye drops (LBAK) in patients with glaucoma or ocular hypertension stabilized with preserved latanoprost eye drops as monotherapy.<br />Methods: Multicenter, randomized, open, two-parallel group study. The intraocular pressure (IOP), ocular signs and symptoms, adverse events and a quality of life questionnaire were evaluated at inclusion (D0) and after 3 months of treatment (D84).<br />Results: One hundred and eighty-three patients were evaluated (38.7 % with an ocular hypertension and 61.3 % with open-angle glaucoma): 130 in the UNL group and 53 in the LBAK group). In the UNL group, mean IOP remained unchanged after 3 months of treatment and the mean difference with LBAK was 0.503mmHg with a confidence interval between -0.202 and 1.208, establishing non-inferiority of UN-L versus BAK-L. Overall, the total score of conjunctival hyperemia improved to a greater extent in the UNL group (-0.5±0.8) compared to the LBAK group (-0.1±0.6, P=0.0004), as well as the total score of symptoms on instillation (-2.0±2.7 versus -0.9±2.2, P=0.0035), and between instillations (-1.8±2.8 vs. -0.3±1.3, P=0.0003).<br />Conclusion: The results of this study showed that preserved latanoprost eye drops may be substituted with unpreserved latanoprost eye drops with better tolerability in glaucoma patients with stable IOP.<br /> (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Female
France
Humans
Latanoprost
Male
Middle Aged
Ophthalmic Solutions
Young Adult
Benzalkonium Compounds administration & dosage
Benzalkonium Compounds adverse effects
Glaucoma, Open-Angle drug therapy
Ocular Hypertension drug therapy
Preservatives, Pharmaceutical administration & dosage
Preservatives, Pharmaceutical adverse effects
Prostaglandins F, Synthetic administration & dosage
Prostaglandins F, Synthetic adverse effects
Subjects
Details
- Language :
- French
- ISSN :
- 1773-0597
- Volume :
- 39
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal francais d'ophtalmologie
- Publication Type :
- Academic Journal
- Accession number :
- 27567675
- Full Text :
- https://doi.org/10.1016/j.jfo.2016.05.006