Back to Search
Start Over
[Timing of Brain Radiation Therapy Impacts Outcomes in Patients with 
Non-small Cell Lung Cancer Who Develop Brain Metastases].
- Source :
-
Zhongguo fei ai za zhi = Chinese journal of lung cancer [Zhongguo Fei Ai Za Zhi] 2016 Aug 20; Vol. 19 (8), pp. 508-14. - Publication Year :
- 2016
-
Abstract
- Background: Radiotherapy combined with chemotherapy or molecular targeted therapy remains the standard of treatment for brain metastases from non-small cell lung cancer (NSCLC). The aim of this study is to determine if the deferral of brain radiotherapy impacts patient outcomes.<br />Methods: Between May 2003 and December 2015, a total of 198 patients with brain metastases from NSCLC who received both brain radiotherapy and systemic therapy (chemotherapy or targeted therapy) were identified. The rate of grade 3-4 adverse reactions related to chemotherapy and radiotherapy had no significant difference between two groups. 127 patients received concurrent brain radiotherapy and systemic therapy, and 71 patients received deferred brain radiotherapy after at least two cycles of chemotherapy or targeted therapy. Disease specific-graded prognostic assessment was similar in early radiotherapy group and deferred radiotherapy group.<br />Results: Median overall survival (OS) was longer in early radiotherapy group compared to deferred radiotherapy group (17.9 months vs 12.6 months; P=0.038). Progression free survival (PFS) was also improved in patients receiving early radiotherapy compared to those receiving deferred radiotherapy (4.0 months vs 3.0 months; P<0.01). Receiving tyrosine kinase inhibitor (TKI) therapy after the diagnosis of brain metastases as any line therapy improved the OS (20.0 months vs 10.7 months; P<0.01), whereas receiving TKI as first line therapy did not (17.9 months vs 15.2 months; P=0.289).<br />Conclusions: Our study suggests that the use of deferred brain radiotherapy may resulted in inferior OS in patients with NSCLC who develop brain metastases. A prospective multi-central randomized study is imminently needed.
- Subjects :
- Brain Neoplasms drug therapy
Combined Modality Therapy
Cranial Irradiation adverse effects
Female
Humans
Male
Middle Aged
Molecular Targeted Therapy
Time Factors
Treatment Outcome
Brain Neoplasms radiotherapy
Brain Neoplasms secondary
Carcinoma, Non-Small-Cell Lung pathology
Cranial Irradiation methods
Lung Neoplasms pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1999-6187
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Zhongguo fei ai za zhi = Chinese journal of lung cancer
- Publication Type :
- Academic Journal
- Accession number :
- 27561799
- Full Text :
- https://doi.org/10.3779/j.issn.1009-3419.2016.08.04