Facile one-pot synthesis of carbon/calcium phosphate/Fe3O4 composite nanoparticles for simultaneous imaging and pH/NIR-responsive drug delivery.

Authors :: Gou M
Li S
Zhang L
Li L
Wang C
Su Z
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2016 Sep 25; Vol. 52 (74), pp. 11068-71. Date of Electronic Publication: 2016 Aug 25.
Publication Year :: 2016
Abstract: A facile one-pot synthetic strategy was explored to synthesize carbon/calcium phosphate/Fe3O4 composite nanoparticles (carbon/CaP/Fe3O4 composite NPs). Taking advantage of the unique structure including mesoporous, small CaP and Fe3O4 subunits homogeneously distributed in a carbon matrix, carbon/CaP/Fe3O4 NPs integrate high drug loading, pH/NIR-sensitive, photothermal and magnetic properties into one nanoplatform for cancer theranostics.

Subjects :: Cell Survival drug effects
Doxorubicin chemistry
Doxorubicin metabolism
Doxorubicin toxicity
Drug Liberation
HeLa Cells
Humans
Hydrogen-Ion Concentration
Magnetics
Microscopy, Confocal
Microscopy, Electron, Scanning
Particle Size
Spectroscopy, Near-Infrared
Spectrum Analysis, Raman
Calcium Phosphates chemistry
Carbon chemistry
Drug Carriers chemistry
Ferrosoferric Oxide chemistry
Nanoparticles chemistry

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