Back to Search
Start Over
Resistance to oral antibiotics in 4569 Gram-negative rods isolated from urinary tract infection in children.
- Source :
-
European journal of pediatrics [Eur J Pediatr] 2016 Sep; Vol. 175 (9), pp. 1219-1225. Date of Electronic Publication: 2016 Aug 24. - Publication Year :
- 2016
-
Abstract
- Unlabelled: To investigate antibiotic resistance among pathogens isolated from urines in a tertiary care children's hospital in Italy. Retrospective analysis of prospectively collected data on antibiotic susceptibility of Gram-negatives isolated from urines at the Istituto Giannina Gaslini, Genoa - Italy from 2007 to 2014. Antibiotic susceptibility was evaluated. By means of CLSI criteria from 2007 to 2010, while from 2011 EUCAST criteria were adopted. Data on susceptibility to amoxicillin-clavulanate, co-trimoxazole, cefuroxime, nitrofurantoin, fosfomycin and ciprofloxacin were evaluated for Escherichia coli, while for other Enterobacteriaceae data were collected for amoxicillin-clavulanate, co-trimoxazole and ciprofloxacin and for ciprofloxacin against Pseudomonas aeruginosa. Univariate and multivariable analyses were performed for risk factors associated with resistance. A total of 4596 Gram-negative strains were observed in 3364 patients. A significant increase in the proportion of resistant strains was observed for E.coli against amoxicillin-clavulanate, cefuroxime and ciprofloxacin and for others Enterobacteriaceae against co-trimoxazole and ciprofloxacin. Resistance to nitrofurantoin and fosfomycin was very infrequent in E.coli. Logistic regression analysis showed that repeated episode of urinary tract infections was a risk factor for E.coli resistance to amoxicillin-clavulanate, co-trimoxazole and cefuroxime, while admission in one of the Units usually managing children with urinary tract malformations was significantly associated to resistance to amoxicillin-clavulanate and cefuroxime.<br />Conclusion: In conclusion the present study shows an increase in antibiotic resistance in pediatric bacteria isolated from urines in children, especially in presence of repeated episodes and/or urinary tract malformations. This resistance is worrisome for beta-lactams and cotrimoxazole, and start to increase also for fluoroquinolones while nitrofurantoin and fosfomycin still could represent useful drugs for oral treatment of these infections.<br />What Is Known: • Infections are frequent in patients with urinary tract malformations • Antibiotic prophylaxis can select for resistant pathogens What is New: • The increase in the resistance to β-lactams, co-trimoxazole or fluoroquinolones in pathogens causing urinary tract infections cause a reduction of drugs with oral formulations available for therapy • Old drugs like nitrofurantoin and fosfomycin can represent attractive compounds for oral treatment of urinary tract infections in children presence of resistance to other drug classes.
- Subjects :
- Child, Preschool
Enterobacteriaceae isolation & purification
Escherichia coli isolation & purification
Female
Humans
Infant
Logistic Models
Male
Pseudomonas aeruginosa isolation & purification
Regression Analysis
Retrospective Studies
Urinary Tract Infections drug therapy
Urinary Tract Infections urine
Anti-Bacterial Agents therapeutic use
Drug Resistance, Bacterial
Enterobacteriaceae drug effects
Escherichia coli drug effects
Pseudomonas aeruginosa drug effects
Urinary Tract Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1076
- Volume :
- 175
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 27558493
- Full Text :
- https://doi.org/10.1007/s00431-016-2763-1