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Factors that promote macrophage homing to adipose tissue in metabolic syndrome.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2016 Nov - Dec; Vol. 30 (8), pp. 1434-1436. Date of Electronic Publication: 2016 Jul 30. - Publication Year :
- 2016
-
Abstract
- Metabolic syndrome (MetS), a common cardio-metabolic cluster, predisposes to both increased cardiovascular disease and diabetes. Both adipose tissue and monocyte/macrophages contribute to the increased inflammation in MetS. However there are sparse data on factors that determine macrophage recruitment into adipose tissue (AT). In this preliminary report in patients with MetS, without the confounding of diabetes and cardiovascular diseases, we show that plasma resistin, soluble CD14 and monocyte p38 MAP kinase activity correlate significantly with AT macrophage density and hence could be important biomediators of macrophage homing to AT in MetS. However larger studies are required to confirm these novel findings and elucidate other important factors.<br /> (Published by Elsevier Inc.)
- Subjects :
- Adult
Aged
Cardiovascular Diseases
Case-Control Studies
Diabetes Mellitus
Female
Humans
Inflammation
Lipopolysaccharide Receptors blood
Male
Middle Aged
Monocytes enzymology
Resistin blood
p38 Mitogen-Activated Protein Kinases metabolism
Adipose Tissue physiopathology
Cell Movement
Macrophages cytology
Metabolic Syndrome physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 27557909
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2016.07.031