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Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients.
- Source :
-
Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2016 Aug; Vol. 74 (8), pp. 626-31. - Publication Year :
- 2016
-
Abstract
- Objectives: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache.<br />Methods: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded.<br />Results: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain.<br />Conclusions: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Migraine Disorders blood
Tension-Type Headache blood
Young Adult
Brain-Derived Neurotrophic Factor blood
Chemokine CCL3 blood
Chemokine CCL5 blood
Migraine Disorders diagnosis
Tension-Type Headache diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1678-4227
- Volume :
- 74
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Arquivos de neuro-psiquiatria
- Publication Type :
- Academic Journal
- Accession number :
- 27556373
- Full Text :
- https://doi.org/10.1590/0004-282X20160096