Back to Search
Start Over
Registry-based randomized controlled trials- what are the advantages, challenges, and areas for future research?
- Source :
-
Journal of clinical epidemiology [J Clin Epidemiol] 2016 Dec; Vol. 80, pp. 16-24. Date of Electronic Publication: 2016 Aug 20. - Publication Year :
- 2016
-
Abstract
- Registry-based randomized controlled trials are defined as pragmatic trials that use registries as a platform for case records, data collection, randomization, and follow-up. Recently, the application of registry-based randomized controlled trials has attracted increasing attention in health research to address comparative effectiveness research questions in real-world settings, mainly due to their low cost, enhanced generalizability of findings, rapid consecutive enrollment, and the potential completeness of follow-up for the reference population, when compared with conventional randomized effectiveness trials. However several challenges of registry-based randomized controlled trials have to be taken into consideration, including registry data quality, ethical issues, and methodological challenges. In this article, we summarize the advantages, challenges, and areas for future research related to registry-based randomized controlled trials.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Comparative Effectiveness Research statistics & numerical data
Humans
Randomized Controlled Trials as Topic statistics & numerical data
Comparative Effectiveness Research methods
Comparative Effectiveness Research trends
Epidemiologic Research Design
Randomized Controlled Trials as Topic methods
Registries statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5921
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Journal of clinical epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 27555082
- Full Text :
- https://doi.org/10.1016/j.jclinepi.2016.08.003