Back to Search
Start Over
A reference panel of 64,976 haplotypes for genotype imputation.
- Source :
-
Nature genetics [Nat Genet] 2016 Oct; Vol. 48 (10), pp. 1279-83. Date of Electronic Publication: 2016 Aug 22. - Publication Year :
- 2016
-
Abstract
- We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 48
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 27548312
- Full Text :
- https://doi.org/10.1038/ng.3643