Back to Search Start Over

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants.

Authors :
Stettler H
Kurka P
Wagner C
Sznurkowska K
Czernicka O
Böhling A
Bielfeldt S
Wilhelm KP
Lenz H
Source :
The Journal of dermatological treatment [J Dermatolog Treat] 2017 May; Vol. 28 (3), pp. 251-257. Date of Electronic Publication: 2016 Aug 22.
Publication Year :
2017

Abstract

Purpose: Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants.<br />Methods: In Study 1 (N = 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N = 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N = 21).<br />Results: In Study 1, mean AUC <subscript>0 - 24 h</subscript> for skin capacitance change from baseline was 302.03 i.u. with NTP-CE and -15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (-45.10 vs. -13.39 g/cm <superscript>2</superscript> , p = .013) and the water gradient increased (0.51 vs. 0.11 g/cm <superscript>4</superscript> , p = .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001).<br />Conclusions: Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants.

Details

Language :
English
ISSN :
1471-1753
Volume :
28
Issue :
3
Database :
MEDLINE
Journal :
The Journal of dermatological treatment
Publication Type :
Academic Journal
Accession number :
27545858
Full Text :
https://doi.org/10.1080/09546634.2016.1218417