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Role of fulvestrant in the treatment of postmenopausal metastatic breast cancer patients.
- Source :
-
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2016 Sep; Vol. 9 (9), pp. 1153-61. Date of Electronic Publication: 2016 Aug 12. - Publication Year :
- 2016
-
Abstract
- Introduction: Endocrine therapy is considered the cornerstone treatment for postmenopausal women with hormone-receptor positive metastatic breast cancer. Fulvestrant is a selective estrogen receptor down-regulator (SERD) with demonstrated activity and efficacy in the treatment of these patients.<br />Areas Covered: The present manuscript aims to review the mechanism of action of fulvestrant, the clinical efficacy data with the use of different dosages and schedules, and finally its role in association with other medications. Expert commentary: Fulvestrant is an active compound with an excellent safety profile for the treatment of women with hormone receptor-positive metastatic breast cancer, The combination of fulvestrant with targeted agents showed increased efficacy and is expected to become a new standard treatment. Results of two clinical trials (i.e. the FALCON and FEVEX trials) are awaited to better clarify the place of fulvestrant in the armamentarium of the available therapies for the treatment of hormone receptor-positive metastatic breast cancer.
- Subjects :
- Antineoplastic Agents, Hormonal adverse effects
Antineoplastic Agents, Hormonal pharmacology
Breast Neoplasms pathology
Estradiol adverse effects
Estradiol pharmacology
Estradiol therapeutic use
Estrogen Receptor Antagonists adverse effects
Estrogen Receptor Antagonists pharmacology
Estrogen Receptor Antagonists therapeutic use
Female
Fulvestrant
Humans
Neoplasm Metastasis
Postmenopause
Treatment Outcome
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms drug therapy
Estradiol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1751-2441
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Expert review of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 27545815
- Full Text :
- https://doi.org/10.1080/17512433.2016.1215243