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High intensity focused ultrasound with Focal-One ® device: Prostate-specific antigen impact and morbidity evaluation during the initial experience.
- Source :
-
Actas urologicas espanolas [Actas Urol Esp] 2016 Dec; Vol. 40 (10), pp. 608-614. Date of Electronic Publication: 2016 Aug 16. - Publication Year :
- 2016
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Abstract
- Objective: We report our initial experience in the treatment of prostate cancer (PCa) with high-intensity focused ultrasound (HIFU) using the Focal-One <superscript>®</superscript> device.<br />Material and Methods: Retrospective review of the prospectively populated database. Between June 2014 to October 2015, 85 patients underwent HIFU (focal/whole-gland) treatment for localized PCa. Preoperative cancer localization was done with multiparametric magnetic resonance imaging (mpMRI) and transperineal mapping biopsies. Treatment was carried out using the Focal-One <superscript>®</superscript> device under general anesthesia. Oncological follow-up: PSA measurement and control biopsy with mpMRI according to protocol. Questionnaire-based functional outcome assessment was done. Complications were reported using Clavien classification.<br />Results: The median PSA was 7.79ng/ml (IQR 6.32-9.16), with a median prostate volume of 38cc (IQR: 33-49.75). Focal and whole-gland therapy was performed in 64 and 21 patients respectively. Ten patients received salvage HIFU. Complications were encountered in 15% of cases, all Clavien 2 graded. Mean hospital stay was 1.8 days (0-7) and bladder catheter was removed on day 2 (1-6). Mean percentage reduction of PSA was 54%. Median follow-up was 3 months (IQR: 2-8). Functional outcomes: All patients were continents at 3 months and potency was maintained in 83% of the preoperatively potent.<br />Conclusions: Focal-One <superscript>®</superscript> HIFU treatment appears to be a safe procedure with few complications. Functional outcomes proved no urinary incontinence and sexual function were maintained in 83%.<br /> (Copyright © 2016. Publicado por Elsevier España, S.L.U.)
- Subjects :
- Aged
Humans
Male
Postoperative Complications epidemiology
Prostatectomy methods
Retrospective Studies
Treatment Outcome
High-Intensity Focused Ultrasound Ablation instrumentation
Prostate-Specific Antigen blood
Prostatectomy instrumentation
Prostatic Neoplasms blood
Prostatic Neoplasms surgery
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1699-7980
- Volume :
- 40
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Actas urologicas espanolas
- Publication Type :
- Academic Journal
- Accession number :
- 27543259
- Full Text :
- https://doi.org/10.1016/j.acuro.2016.04.016