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Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease.
- Source :
-
Journal of translational medicine [J Transl Med] 2016 Aug 19; Vol. 14 (1), pp. 243. Date of Electronic Publication: 2016 Aug 19. - Publication Year :
- 2016
-
Abstract
- Background: Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown.<br />Methods: PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD).<br />Results: The CAD-DM2 patients had significantly lower PGC1α and UCP1 expression in epicardial adipose tissue than the CAD-NDM2 and NCAD patients. However, PGC1α and UCP1 mRNA trended upward in subcutaneous adipose tissue from CAD-DM2 patients. At multiple regression analysis, age, body mass index, left ventricular ejection fraction, UCP1 expression of epicardial adipose tissue and diabetes came out to be independent predictors of PGC1α levels. Epicardial adipose tissue PGC1α expression was dependent on the number of injured coronary arteries and logistic regression analysis showed that PGC1α expression in epicardial adipose tissue could exert a protective effect against coronary lesions.<br />Conclusions: DM2 is associated with decreased expression of PGC1α and UCP1 mRNA in epicardial adipose tissue of patients with CAD, likely reflecting a loss of brown-like fat features. Decreased expression of PGC1α in human epicardial adipose tissue is associated with higher prevalence of coronary lesions.
- Subjects :
- Coronary Artery Disease pathology
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Diabetes Mellitus, Type 2 pathology
Female
Gene Expression Regulation
Humans
Logistic Models
Male
Middle Aged
Pericardium pathology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Subcutaneous Fat metabolism
Thermogenesis genetics
Transcription Factors genetics
Transcription Factors metabolism
Uncoupling Protein 1 genetics
Uncoupling Protein 1 metabolism
Adipose Tissue metabolism
Coronary Artery Disease complications
Coronary Artery Disease genetics
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 genetics
Pericardium metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1479-5876
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of translational medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27542888
- Full Text :
- https://doi.org/10.1186/s12967-016-0999-1