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An Observational Study to Evaluate Associations Between Low-Level Gestational Exposure to Organophosphate Pesticides and Cognition During Early Childhood.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2016 Sep 01; Vol. 184 (5), pp. 410-8. Date of Electronic Publication: 2016 Aug 18. - Publication Year :
- 2016
-
Abstract
- Prenatal exposure to organophosphate pesticides, which is ubiquitous, may be detrimental to neurological development. We examined 327 mother/infant pairs in Cincinnati, Ohio, between 2003 and 2006 to determine associations between prenatal exposure to organophosphate pesticides and neurodevelopment. Twice during pregnancy urinary concentrations of 6 common dialkylphosphates, nonspecific metabolites of organophosphate pesticides, were measured. Aggregate concentrations of diethylphosphates, dimethylphosphates, and total dialkylphosphates were calculated. Bayley Scales of Infant Development, Second Edition-Mental and Psychomotor Developmental indices were administered at ages 1, 2, and 3 years, the Clinical Evaluation of Language Fundamentals-Preschool, Second Edition, at age 4, and the Wechsler Preschool and Primary Scale of Intelligence, Third Edition, at age 5. Mothers with higher urinary total dialkylphosphate concentrations reported higher levels of socioeconomic status and increased fresh fruit and vegetable intake. We found no associations between prenatal exposure to organophosphate pesticides and cognition at 1-5 years of age. In our cohort, exposure to organophosphate pesticides during pregnancy was not associated with cognition during early childhood. It is possible that a higher socioeconomic status and healthier diet may protect the fetus from potential adverse associations with gestational organophosphate pesticide exposure, or that dietary exposure to the metabolites is innocuous and not an ideal measure of exposure to the parent compound.<br /> (© The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Child, Preschool
Cognition Disorders epidemiology
Confounding Factors, Epidemiologic
Diet
Female
Humans
Infant
Male
Maternal Age
Nervous System growth & development
Ohio epidemiology
Organophosphates urine
Pesticides adverse effects
Pesticides urine
Pregnancy
Prenatal Exposure Delayed Effects urine
Prenatal Nutritional Physiological Phenomena
Social Class
Child Development drug effects
Cognition Disorders chemically induced
Nervous System drug effects
Organophosphates adverse effects
Prenatal Exposure Delayed Effects epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 184
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 27539379
- Full Text :
- https://doi.org/10.1093/aje/kwv447