Back to Search
Start Over
The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Sep 23; Vol. 478 (3), pp. 1136-40. Date of Electronic Publication: 2016 Aug 15. - Publication Year :
- 2016
-
Abstract
- Estrogen deficiency-induced obesity has a high risk of visceral fat accumulation and body weight gain. It is also associated with many adverse health conditions. Taheebo extract from Tabebuia avellanedae has been recognized as playing several biological and pharmacological roles. Therefore, we investigated whether the intake of n-BuOH extract of Taheebo shows anti-obesity effect in ovariectomized (OVX) mice. After 16 weeks of feeding, the mice administrated with 0.5% n-BuOH extract of Taheebo showed significantly decreased body weight compared with that of the control mice, and the fat mass also showed a significant decrease. In 3T3-L1 cells, supplementation with n-BuOH extract of Taheebo significantly reduced the triglyceride (TG) levels. Furthermore, bioassay-guided purification of the n-BuOH extract based on the TG levels in 3T3-L1 cells led to the isolation of compound 2 (1-dehydroxy-3,4-dihydroaucubigenin). These results suggested that the anti-obesity effect of Taheebo extract is due to its capability in preventing the accumulation of adipocyte in mice. Taheebo extract might be a promising functional food resources capable of protecting against OVX-induced obesity.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- 1-Butanol chemistry
3T3-L1 Cells
Animals
Anti-Obesity Agents pharmacology
Body Weight drug effects
Cell Survival drug effects
Feces chemistry
Female
Liver drug effects
Liver metabolism
Mice
Obesity blood
Organ Size drug effects
Ovariectomy
Plant Extracts chemistry
Plant Extracts isolation & purification
Plant Extracts pharmacology
Triglycerides metabolism
Anti-Obesity Agents therapeutic use
Obesity drug therapy
Plant Extracts therapeutic use
Tabebuia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 478
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27539320
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.08.081