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Interobserver variability in gross tumor volume delineation for hepatocellular carcinoma : Results of Korean Radiation Oncology Group 1207 study.
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2016 Oct; Vol. 192 (10), pp. 714-21. Date of Electronic Publication: 2016 Aug 18. - Publication Year :
- 2016
-
Abstract
- Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC.<br />Patients and Methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated.<br />Results: The median kappa agreement level was 0.71 (range 0.28-0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 % (median 26 %).<br />Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Neoplasm Staging
Observer Variation
Reproducibility of Results
Republic of Korea
Sensitivity and Specificity
Carcinoma, Hepatocellular diagnostic imaging
Carcinoma, Hepatocellular pathology
Clinical Competence
Liver Neoplasms diagnostic imaging
Liver Neoplasms pathology
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1439-099X
- Volume :
- 192
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 27538775
- Full Text :
- https://doi.org/10.1007/s00066-016-1028-2