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Emerging drugs for the treatment of kidney disease-induced anemia.
- Source :
-
Expert opinion on emerging drugs [Expert Opin Emerg Drugs] 2016 Sep; Vol. 21 (3), pp. 315-30. Date of Electronic Publication: 2016 Aug 22. - Publication Year :
- 2016
-
Abstract
- Introduction: Anemia has been remained one of the most characteristic and visible manifestations of chronic renal failure. Correction of anemia requires two main treatment strategies: increased stimulation of erythropoiesis, and maintenance of an adequate iron supply to the bone marrow.<br />Areas Covered: Erythropoiesis activating agents became a mainstay in the treatment of renal anemia for more than 25 years. Recently, there have been several attempts to introduce new drugs to stimulate erythropoiesis or affect the hepcidin-ferroportin pathway. Orally available hypoxia-inducible factor (HIF) stabilizing compounds are attractive alternatives. They not only increase hemoglobin, but also suppress hepcidin production and improve iron availability. Novel iron preparations, may also help to ameliorate anemia, with acceptable safety profile and other beneficial properties such a phosphate binding.<br />Expert Opinion: One should be aware of potential risks and benefits of novel sophisticated therapies and their role in the management of renal anemia remain to be established. In particular HIF stabilizers needs to be proven safe, or even safer than ESAs, in large long-term safety studies testing hard end points, due its ubiquitous nature and the regulation of variety of biological processes potentially leading to unexpected side effects. Besides safety, cost-effectiveness appears the major issue in the modern world, including nephrology.
- Subjects :
- Anemia etiology
Animals
Basic Helix-Loop-Helix Transcription Factors metabolism
Hematinics adverse effects
Hematinics pharmacology
Hematinics therapeutic use
Humans
Hypoxia-Inducible Factor 1 metabolism
Iron Compounds administration & dosage
Iron Compounds adverse effects
Anemia drug therapy
Drug Design
Kidney Failure, Chronic complications
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7623
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Expert opinion on emerging drugs
- Publication Type :
- Academic Journal
- Accession number :
- 27537859
- Full Text :
- https://doi.org/10.1080/14728214.2016.1220537