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The Treatment and Outcomes of Extraskeletal Osteosarcoma: Institutional Experience and Review of The Literature.
- Source :
-
The Iowa orthopaedic journal [Iowa Orthop J] 2016; Vol. 36, pp. 98-103. - Publication Year :
- 2016
-
Abstract
- Background: Extraskeletal osteosarcoma is a rare tumor with a poor prognosis. The purpose of this study is to examine the oncologic outcomes of this disease as they relate to surgical treatment and use of adjuvant therapies.<br />Methods: We retrospectively analyzed all patients treated at our institution for high-grade extraskeletal osteosarcoma of the limb or chest wall. We recorded demographic data, presenting stage, surgical margin, use of adjuvant chemotherapy or radiation, incidence of local recurrence, metastases, and death. Overall and event-free survival were calculated using Kaplan-Meier survival methods.<br />Results: There were 12 patients treated with primary wide resection or re-excision of a previously operated tumor bed. Four patients presented with metastases. Seven patients received chemotherapy and four patients received radiation therapy. There were two local recurrences, six patients developed new metastases, and nine patients died. There was no difference in overall survival in patients who received chemotherapy. There was, however, a trend towards increased length of survival in patients who received chemotherapy compared to those who did not (16.4 months vs. 9.3 months, p=0.16).<br />Conclusions: Despite no difference in overall survival, patients treated with adjuvant chemotherapy have a trend towards increased length of survival. We suggest that extraskeletal osteosarcoma be treated with standard osteosarcoma chemotherapy regimens in addition to wide resection.
- Subjects :
- Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Osteosarcoma mortality
Osteosarcoma pathology
Prognosis
Radiotherapy, Adjuvant
Soft Tissue Neoplasms mortality
Soft Tissue Neoplasms pathology
Survival Rate
Thigh pathology
Thoracic Wall pathology
Treatment Outcome
Antineoplastic Agents therapeutic use
Osteosarcoma therapy
Soft Tissue Neoplasms therapy
Thigh surgery
Thoracic Wall surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1555-1377
- Volume :
- 36
- Database :
- MEDLINE
- Journal :
- The Iowa orthopaedic journal
- Publication Type :
- Academic Journal
- Accession number :
- 27528844