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Torque Teno Virus Load-Inverse Association With Antibody-Mediated Rejection After Kidney Transplantation.
- Source :
-
Transplantation [Transplantation] 2017 Feb; Vol. 101 (2), pp. 360-367. - Publication Year :
- 2017
-
Abstract
- Background: Antibody-mediated rejection (AMR) represents one of the cardinal causes of late allograft loss after kidney transplantation, and there is great need for noninvasive tools improving early diagnosis of this rejection type. One promising strategy might be the quantification of peripheral blood DNA levels of the highly prevalent and apathogenic Torque Teno virus (TTV), which might mirror the overall level of immunosuppression and thus help determine the risk of alloimmune response.<br />Methods: To assess the association between TTV load in the peripheral blood and AMR, 715 kidney transplant recipients (median, 6.3 years posttransplantation) were subjected to a systematical cross-sectional AMR screening and, in parallel, TTV quantification.<br />Results: Eighty-six of these recipients had donor-specific antibodies and underwent protocol biopsy, AMR-positive patients (n = 46) showed only 25% of the TTV levels measured in patients without AMR (P = 0.003). In a generalized linear model, higher TTV levels were associated with a decreased risk for AMR after adjustment for potential confounders (risk ratio 0.94 per TTV log level; 95% confidence interval 0.90-0.99; P = 0.02).<br />Conclusions: Future studies will have to clarify whether longitudinal assessment of TTV load might predict AMR risk and help guide the type and intensity of immunosuppression to prevent antibody-mediated graft injury.<br />Competing Interests: The authors declare no conflicts of interest.
- Subjects :
- Adult
Biomarkers blood
Biopsy
Chi-Square Distribution
Cross-Sectional Studies
DNA, Viral genetics
Female
Graft Rejection blood
Graft Rejection diagnosis
Graft Rejection virology
Humans
Immunity, Humoral
Immunocompromised Host
Immunosuppressive Agents therapeutic use
Linear Models
Logistic Models
Male
Middle Aged
Odds Ratio
Prospective Studies
Risk Factors
Time Factors
Torque teno virus genetics
Torque teno virus immunology
Treatment Outcome
Viral Load
Graft Rejection immunology
Isoantibodies blood
Kidney Transplantation adverse effects
Torque teno virus pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6080
- Volume :
- 101
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 27525643
- Full Text :
- https://doi.org/10.1097/TP.0000000000001455