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Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
- Source :
-
Obesity research & clinical practice [Obes Res Clin Pract] 2017 Mar - Apr; Vol. 11 (2), pp. 227-232. Date of Electronic Publication: 2016 Aug 11. - Publication Year :
- 2017
-
Abstract
- Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI. SEPP1 mRNA was correlated negatively with BMI, suggesting there may be tissue specific regulation. This study suggests that obesity, rather than insulin resistance, is central to the increase in SeP.<br /> (Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1871-403X
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Obesity research & clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 27524654
- Full Text :
- https://doi.org/10.1016/j.orcp.2016.07.004