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Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2017 May; Vol. 139 (5), pp. 1591-1599.e2. Date of Electronic Publication: 2016 Aug 12. - Publication Year :
- 2017
-
Abstract
- Background: Hen's egg is the most common cause of food allergy in early childhood.<br />Objective: We investigated the efficacy and safety of early hen's egg introduction at age 4 to 6 months to prevent hen's egg allergy in the general population.<br />Methods: This randomized, placebo-controlled trial included 4- to 6-month-old infants who were not sensitized against hen's egg, as determined based on specific serum antibodies (IgE). These infants were randomized to receive either verum (egg white powder) or placebo (rice powder) added to the first weaning food 3 times a week under a concurrent egg-free diet from age 4 to 6 until 12 months. The primary outcome was sensitization to hen's egg (increased specific serum IgE levels) by age 12 months. Hen's egg allergy (secondary outcome) was confirmed by double-blind, placebo-controlled food challenges.<br />Results: Among 406 screened infants, 23 (5.7%) had hen's egg-specific IgE before randomization. Seventeen of 23 underwent subsequent double-blind, placebo-controlled food challenges, and 16 were confirmed as allergic, including 11 with anaphylactic reactions. Of the 383 nonsensitized infants (56.7% male), 184 were randomized to verum and 199 to placebo. At 12 months of age, 5.6% of the children in the verum group were hen's egg sensitized versus 2.6% in the placebo group (primary outcome; relative risk, 2.20; 95% CI, 0.68-7.14; P = .24), and 2.1% were confirmed to have hen's egg allergy versus 0.6% in the placebo group (relative risk, 3.30; 95% CI, 0.35-31.32; P = .35).<br />Conclusion: We found no evidence that consumption of hen's egg starting at 4 to 6 months of age prevents hen's egg sensitization or allergy. In contrast, it might result in frequent allergic reactions in the community considering that many 4- to 6-month-old infants were already allergic to hen's egg.<br /> (Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Anaphylaxis blood
Anaphylaxis diagnosis
Anaphylaxis etiology
Anaphylaxis prevention & control
Animals
Chickens
Double-Blind Method
Egg Hypersensitivity blood
Egg Hypersensitivity diagnosis
Egg Hypersensitivity immunology
Egg Proteins adverse effects
Egg Proteins immunology
Egg White adverse effects
Female
Humans
Immunoglobulin E blood
Infant
Male
Primary Prevention
Egg Hypersensitivity prevention & control
Egg Proteins administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 139
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27523961
- Full Text :
- https://doi.org/10.1016/j.jaci.2016.06.045