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The Influence of Statin Therapy on Restenosis in Patients Who Underwent Nitinol Stent Implantation for de Novo Femoropopliteal Artery Disease: Two-Year Follow-up at a Single Center.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2016 Oct; Vol. 27 (10), pp. 1494-501. Date of Electronic Publication: 2016 Aug 10. - Publication Year :
- 2016
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Abstract
- Purpose: To determine whether statin therapy is associated with reduced restenosis following nitinol stent implantation for de novo femoropopliteal artery disease.<br />Materials and Methods: A total of 135 limbs in 135 patients (mean age, 72 y) implanted with nitinol stents in femoropopliteal occlusions were analyzed (statin arm, n = 91; nonstatin arm, n = 44). The patients were treated with one type of nitinol stent.<br />Results: At baseline, lesions and procedural characteristics were comparable between groups, except that the statin group had more hypertension, coronary artery disease, and hyperlipidemia. There were significant differences in the incidence of binary restenosis between groups at 1 year (45.5% for nonstatin group vs 28.6% for statin group; P = .05) and 2 years (56.8% for nonstatin group vs 38.5% for statin group; P = .04). Primary patency rates at 1 year were 50.5% in the nonstatin group and 72.5% in the statin group (P = .01). Two-year target lesion revascularization rates were 54.5% in the nonstatin group and 35.2% in the statin group (P = .03). On univariate analysis, statin therapy was associated with decreased relative risk of binary restenosis at 1 year (odds ratio [OR], 0.480; 95% confidence interval [CI], 0.227-1.014; P = .050). On multivariate analysis, statin therapy did not significantly affect the odds of binary restenosis (OR, 0.415; 95% CI, 0.071-2.437; P = .330).<br />Conclusions: The incidence of binary restenosis was significantly lower in the statin group than in the nonstatin group following nitinol stent implantation for de novo femoropopliteal artery disease.<br /> (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Endovascular Procedures adverse effects
Female
Florida
Follow-Up Studies
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Peripheral Arterial Disease diagnostic imaging
Peripheral Arterial Disease physiopathology
Prosthesis Design
Protective Factors
Recurrence
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Vascular Patency
Alloys
Endovascular Procedures instrumentation
Femoral Artery diagnostic imaging
Femoral Artery physiopathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Peripheral Arterial Disease therapy
Popliteal Artery diagnostic imaging
Popliteal Artery physiopathology
Stents
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 27
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 27522274
- Full Text :
- https://doi.org/10.1016/j.jvir.2016.05.037