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Internal limiting membrane transplantation for unclosed and large macular holes.
- Source :
-
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2016 Nov; Vol. 254 (11), pp. 2095-2099. Date of Electronic Publication: 2016 Aug 12. - Publication Year :
- 2016
-
Abstract
- Background: To present the surgical technique and clinical outcomes of transplantation of autologous internal limiting membrane (ILM) for large macular holes (MHs) after failed surgeries with ILM removal.<br />Methods: Thirteen eyes of 13 consecutive patients with MHs larger than 500 μm after failed surgeries with ILM removal underwent vitrectomy with transplantation of autologous ILM. In the ILM transplantation technique, a small piece of the ILM was peeled off and transplanted inside the macular hole. Fluid-air exchange was then performed. The air was then replaced with 10 % perfluoropropane (C <subscript>3</subscript> F <subscript>8</subscript> ) gas. Comprehensive ophthalmologic examinations and spectral-domain optical coherence tomography were performed preoperatively and postoperatively. The main outcome measures were best-corrected Snellen visual acuity (BCVA) and MH closure rate.<br />Results: The preoperative mean base diameter of the MHs was 1637.6 + 412.7 μm (range, 814-2092 μm). The preoperative mean minimum diameter was 814.4 + 255.0 μm (range, 546 μm-1485 μm). Complete MH sealing was achieved in 12 eyes after transplantation of the ILM flap. The mean BCVA was 1.15 + 0.21 (range, 1.0-1.6) before surgery and 0.99 + 0.17 (range, 0.7-1.3) at 12 months postoperatively. There was a significant difference in BCVA before versus after the surgery (t = 3.825, P = 0.0002, paired t- test).<br />Conclusions: Transplantation of autologous ILM is an effective addition to the surgical options for large macular holes after failed surgeries with ILM removal.
- Subjects :
- Adult
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Reoperation
Retinal Perforations diagnosis
Retinal Perforations surgery
Tomography, Optical Coherence
Treatment Outcome
Young Adult
Basement Membrane transplantation
Ophthalmologic Surgical Procedures methods
Retinal Perforations therapy
Visual Acuity
Subjects
Details
- Language :
- English
- ISSN :
- 1435-702X
- Volume :
- 254
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- Publication Type :
- Academic Journal
- Accession number :
- 27520464
- Full Text :
- https://doi.org/10.1007/s00417-016-3461-4