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CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.

Authors :
Myles IA
Zhao M
Nardone G
Olano LR
Reckhow JD
Saleem D
Break TJ
Lionakis MS
Myers TG
Gardina PJ
Kirkpatrick CH
Holland SM
Datta SK
Source :
Journal of leukocyte biology [J Leukoc Biol] 2017 Jan; Vol. 101 (1), pp. 307-320. Date of Electronic Publication: 2016 Aug 11.
Publication Year :
2017

Abstract

Cellular lysates from PPD <superscript>+</superscript> donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by these reported phenomena, we found that the cellular extract derived from antigen-specific memory CD8 <superscript>+</superscript> T cells induces IL-6 from antigen-matched APCs. This ultimately elicits IL-17 from bystander memory CD8 <superscript>+</superscript> T cells. We have identified that dialyzable peptide sequences, S100a9, and the TCR β chain from CD8 <superscript>+</superscript> T cells contribute to the molecular nature of this activity. We further show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans These effects are sensitive to immunization protocols and extraction methodology in ways that may explain past discrepancies in the reproducibility of passive cellular immunity.<br /> (© Society for Leukocyte Biology.)

Details

Language :
English
ISSN :
1938-3673
Volume :
101
Issue :
1
Database :
MEDLINE
Journal :
Journal of leukocyte biology
Publication Type :
Academic Journal
Accession number :
27515950
Full Text :
https://doi.org/10.1189/jlb.3A0216-082R