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CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.
- Source :
-
Journal of leukocyte biology [J Leukoc Biol] 2017 Jan; Vol. 101 (1), pp. 307-320. Date of Electronic Publication: 2016 Aug 11. - Publication Year :
- 2017
-
Abstract
- Cellular lysates from PPD <superscript>+</superscript> donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by these reported phenomena, we found that the cellular extract derived from antigen-specific memory CD8 <superscript>+</superscript> T cells induces IL-6 from antigen-matched APCs. This ultimately elicits IL-17 from bystander memory CD8 <superscript>+</superscript> T cells. We have identified that dialyzable peptide sequences, S100a9, and the TCR β chain from CD8 <superscript>+</superscript> T cells contribute to the molecular nature of this activity. We further show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans These effects are sensitive to immunization protocols and extraction methodology in ways that may explain past discrepancies in the reproducibility of passive cellular immunity.<br /> (© Society for Leukocyte Biology.)
- Subjects :
- Animals
Epitopes immunology
Humans
Immunity
Immunologic Memory
Interleukin-17 metabolism
Lymphocyte Activation immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Models, Biological
Receptors, Antigen, T-Cell metabolism
S100 Proteins metabolism
Spleen pathology
Antigens metabolism
CD8-Positive T-Lymphocytes immunology
Dendritic Cells immunology
Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3673
- Volume :
- 101
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of leukocyte biology
- Publication Type :
- Academic Journal
- Accession number :
- 27515950
- Full Text :
- https://doi.org/10.1189/jlb.3A0216-082R