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Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France.
- Source :
-
Veterinary parasitology [Vet Parasitol] 2016 Aug 15; Vol. 226, pp. 88-92. Date of Electronic Publication: 2016 Jun 25. - Publication Year :
- 2016
-
Abstract
- Resistance to ivermectin and moxidectin was explored by a faecal egg count reduction test in two sheep flocks with suspected anthelmintic resistance. The FECRT confirmed one suspicion, with a mean percentage of reduction in egg excretion within the treated groups of 0% for ivermectin (CI 95%: -228 to 58) and 13% for moxidectin (CI 95%: -152 to 70). This was further explored by a controlled efficacy test. An experimental infection of 18 naïve lambs was set up using infective larvae isolated from this flock (5000 L3/lamb). Compared to the control group, abomasal worm burdens (Teladorsagia circumcincta) were reduced by 90% [CI 95%: 81.5-94.8] and 85% [CI 95%: 72.4-92.2] after ivermectin (p<0.05) and moxidectin (p<0.05) treatment respectively. Again, compared to the control group, there was a reduction for intestinal strongyles (Trichostrongylus colubriformis) of 100% and 99% [CI 95%: 97.5-99.7] for ivermectin and moxidectin respectively. No difference was found between the efficacy of moxidectin and ivermectin. Pharmacokinetic values indicated that the strongyles were submitted to anthelmintic concentrations usually lethal to them. This trial demonstrated the first multiple resistance of ovine strongyles in France.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Abomasum parasitology
Animals
Antinematodal Agents therapeutic use
Cecum parasitology
Drug Resistance
Feces parasitology
Female
France
Intestine, Small parasitology
Ivermectin therapeutic use
Macrolides therapeutic use
Male
Nematode Infections drug therapy
Nematode Infections parasitology
Parasite Egg Count veterinary
Sheep
Sheep Diseases parasitology
Trichostrongyloidea isolation & purification
Trichostrongyloidiasis drug therapy
Trichostrongyloidiasis parasitology
Trichostrongyloidiasis veterinary
Trichostrongylus drug effects
Trichostrongylus isolation & purification
Antinematodal Agents pharmacology
Ivermectin pharmacology
Macrolides pharmacology
Nematode Infections veterinary
Sheep Diseases drug therapy
Trichostrongyloidea drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2550
- Volume :
- 226
- Database :
- MEDLINE
- Journal :
- Veterinary parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 27514891
- Full Text :
- https://doi.org/10.1016/j.vetpar.2016.06.033