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Baseline metabolic disturbances and the twenty-five years risk of incident cancer in a Mediterranean population.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2016 Nov; Vol. 26 (11), pp. 1020-1025. Date of Electronic Publication: 2016 Jul 12. - Publication Year :
- 2016
-
Abstract
- Background and Aims: Obesity is predictive of metabolic syndrome (metS), type 2 diabetes, cardiovascular (CV) disease and cancer. The aim of the study is to assess the risk of incident cancer connected to obesity and metS in a Mediterranean population characterized by a high prevalence of obesity.<br />Methods and Results: As many as 1133 subjects were enrolled in two phases and followed for 25 years (859 subjects) or 11 years (274 subjects) and incident cancer was registered in the follow-up period. Anthropometric measures and biochemical parameters were filed at baseline and evaluated as predictors of incident cancer by measuring hazards ratios (HR) using multivariate Cox parametric hazards models. Best predictive threshold for metabolic parameters and metS criteria were recalculated by ROC analysis. Fasting Blood Glucose >5.19 mmol/L [HR = 1.58 (1.0-2.4)] and the TG/HDL ratio (log <subscript>10</subscript> ) (Males > 0.225, Females > 0.272) [HR = 2.44 (1.3-4.4)] resulted independent predictors of survival free of cancer with a clear additive effect together with age classes [45-65 years, HR = 2.47 (1.3-4.4), 65-75 years HR = 3.80 (2.0-7.1)] and male gender [HR = 2.07 (2.3-3.1)].<br />Conclusions: Metabolic disturbances are predictive of cancer in a 25 years follow-up of a Mediterranean population following a traditional Mediterranean diet. The high prevalence of obesity and metS and the observed underlying condition of insulin resistance expose this population to an increased risk of cardiovascular disease and cancer despite the healthy nutritional habits.<br /> (Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Area Under Curve
Biomarkers blood
Blood Glucose metabolism
Cardiovascular Diseases diagnosis
Cardiovascular Diseases prevention & control
Chi-Square Distribution
Diet, Healthy
Diet, Mediterranean
Disease-Free Survival
Female
Humans
Incidence
Insulin Resistance
Italy epidemiology
Lipids blood
Male
Metabolic Syndrome blood
Metabolic Syndrome diagnosis
Middle Aged
Multivariate Analysis
Neoplasms diagnosis
Neoplasms prevention & control
Obesity diagnosis
Prevalence
Proportional Hazards Models
Protective Factors
ROC Curve
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Cardiovascular Diseases epidemiology
Metabolic Syndrome epidemiology
Neoplasms epidemiology
Obesity epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 27511705
- Full Text :
- https://doi.org/10.1016/j.numecd.2016.07.003