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Combined presence of multiple gastrointestinal stromal tumors along with duodenal submucosal somatostatinoma in a patient with neurofibromatosis type 1.
- Source :
-
Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2016 Jul-Sep; Vol. 59 (3), pp. 359-61. - Publication Year :
- 2016
-
Abstract
- Neurofibromatosis type-1 (NF-1) is an autosomal dominant disorder, with increased risk of developing benign and malignant tumors of the gastrointestinal tract (GIT). However, the synchronous presence of multiple GIT stromal tumors and duodenal submucosal somatostatinoma, like in this 50-year-old female NF-1 patient, is very rare. She presented with hematemesis, malena, along with multiple neurofibromas all over the body. Thorough radiological and peroperative work-up revealed multiple ulcerated submucosal and serosal nodules in the proximal small intestine. Histological work-up revealed diagnosis of a duodenal submucosal somatostatinoma with multifocal serosal gastrointestinal stromal tumors. This case is being reported to highlight the rare coincidence of multiple GIT tumors in an NF-1 patient.
- Subjects :
- Biomarkers, Tumor analysis
Female
Gastrointestinal Stromal Tumors diagnostic imaging
Gastrointestinal Stromal Tumors pathology
Hematemesis etiology
Histocytochemistry
Humans
Immunohistochemistry
Intestine, Small pathology
Melena etiology
Microscopy
Middle Aged
Neurofibromatosis 1 pathology
Radiography, Abdominal
Somatostatin analysis
Somatostatinoma diagnostic imaging
Somatostatinoma pathology
Synaptophysin analysis
Tomography, X-Ray Computed
Gastrointestinal Stromal Tumors complications
Gastrointestinal Stromal Tumors diagnosis
Neurofibromatosis 1 complications
Neurofibromatosis 1 diagnosis
Somatostatinoma complications
Somatostatinoma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0974-5130
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Indian journal of pathology & microbiology
- Publication Type :
- Report
- Accession number :
- 27510677
- Full Text :
- https://doi.org/10.4103/0377-4929.188123