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DNA-reactive B cells in lupus.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2016 Dec; Vol. 43, pp. 1-7. Date of Electronic Publication: 2016 Aug 06. - Publication Year :
- 2016
-
Abstract
- IgG anti-DNA antibodies are both diagnostic and pathogenic for systemic lupus erythematosus (SLE). They contribute to tissue inflammation through direct tissue binding and to systemic inflammation through activation of Toll-like receptors by nucleic acid-containing immune complexes. IgG DNA-reactive antibodies originate when B cell tolerance mechanisms are impaired. The heterogeneous immune perturbations in SLE lead to the survival and activation of DNA-reactive B cells in various B cell subsets at distinct stages of B cell maturation and differentiation. We propose that the spectrum of B cell alterations and failed tolerance mechanisms for DNA-reactive B cells in lupus patients is best understood by studying genetic risk alleles. This implies that the B cells producing IgG anti-DNA antibodies and the failed tolerance mechanisms(s) will differ across patients. A better understanding of these differences should lead to better patient stratification, improved outcomes of clinical trials, and the identification of novel therapeutic targets.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alleles
Animals
Antibodies, Antinuclear genetics
Genetic Predisposition to Disease
Genotype
Humans
Immune Tolerance
Lupus Erythematosus, Systemic genetics
Risk
Antibodies, Antinuclear metabolism
B-Lymphocyte Subsets immunology
B-Lymphocytes immunology
DNA immunology
Lupus Erythematosus, Systemic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0372
- Volume :
- 43
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27504587
- Full Text :
- https://doi.org/10.1016/j.coi.2016.07.002