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Reactive hyperemia is associated with adverse clinical outcomes in heart failure.
- Source :
-
American heart journal [Am Heart J] 2016 Aug; Vol. 178, pp. 108-14. Date of Electronic Publication: 2016 May 20. - Publication Year :
- 2016
-
Abstract
- Introduction: Impaired endothelial function, as assessed by brachial artery flow-mediated dilation (FMD), is an established risk factor for cardiovascular events. FMD is impaired in heart failure (HF) patients, but less is known about hyperemic brachial artery flow. We investigated the relationship between FMD and hyperemic flow with adverse clinical outcomes in HF patients.<br />Methods: Brachial artery FMD and hyperemic flow were assessed in 156 patients (70.5 % Male; 45.5% Caucasian; mean age (± SD) = 56.2 (±12.4) years) with HF and reduced left ventricular ejection fraction (LVEF). Cox proportional hazard models were used to assess the potential explanatory association of FMD and hyperemic flow with the composite outcome of death or cardiovascular hospitalization over a median 5-year follow-up period.<br />Results: Both FMD and hyperemic flow were negatively correlated with age, but unrelated to sex, race, body mass index, LVEF or N-terminal pro-B-Type natriuretic peptide (NT-ProBNP). Reduced hyperemic flow, but not FMD, was associated with an increased risk of death or cardiac hospitalization after controlling for traditional risk factors.<br />Conclusion: The association of reduced hyperemic flow with increased risk of adverse clinical outcomes suggests that micro-vascular function may be an important prognostic marker in patients with HF.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Brachial Artery physiopathology
Endothelium, Vascular physiopathology
Female
Heart Failure blood
Heart Failure mortality
Heart Failure physiopathology
Hospitalization
Humans
Hyperemia physiopathology
Laser-Doppler Flowmetry
Male
Middle Aged
Mortality
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Prognosis
Proportional Hazards Models
Risk Factors
Stroke Volume
Heart Failure epidemiology
Hyperemia epidemiology
Vasodilation
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6744
- Volume :
- 178
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 27502858
- Full Text :
- https://doi.org/10.1016/j.ahj.2016.05.008