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Asthma-COPD overlap syndrome (ACOS) vs 'pure' COPD: a distinct phenotype?
- Source :
-
Allergy [Allergy] 2017 Jan; Vol. 72 (1), pp. 137-145. Date of Electronic Publication: 2016 Sep 27. - Publication Year :
- 2017
-
Abstract
- Background: Some studies suggest that asthma-COPD overlap syndrome (ACOS) is associated with worse outcomes than chronic obstructive pulmonary disease (COPD). The goal of this study was to further explore the clinical characteristics and survival of patients with ACOS identified in a real-life cohort of patients with COPD.<br />Methods: Data from the French COPD cohort 'INITIATIVES BronchoPneumopathie Chronique Obstructive' (n = 998 patients) were analyzed to assess the frequency of ACOS defined as a physician diagnosis of asthma before the age of 40 years and to analyze its impact. Univariate analyses were performed to assess the relationship between ACOS and sociodemographic characteristics, risk factors (smoking, occupational exposure, atopic diseases), symptoms (chronic bronchitis, dyspnea-modified Medical Research Council scale and baseline dyspnea index), quality of life (QoL), mood disorders, exacerbations, comorbidities, lung function, prescribed treatment, and survival.<br />Results: ACOS was diagnosed in 129 patients (13%). In multivariate analyses, ACOS was associated negatively with cumulative smoking (odds ratio [OR]: 0.992; 95% CI 0.984-1.000 per pack-year) and positively with obesity: OR: 1.97 [1.22-3.16], history of atopic disease (hay fever: OR: 5.50 [3.42-9.00] and atopic dermatitis: OR 3.76 [2.14-6.61]), and drug use (LABA + ICS: 1.86 [1.27-2.74], antileukotrienes 4.83 [1.63-14.34], theophylline: 2.46 [1.23-4.91], and oral corticosteroids: [2.99;.1.26-7.08]). No independent association was found with dyspnea, QoL, exacerbations, and mortality.<br />Conclusions: Compared to 'pure' COPD patients, patients with ACOS exhibit lower cumulative smoking, suffer more from obesity and atopic diseases, and use more asthma treatments. Disease severity (dyspnea, QoL, exacerbations, comorbidities) and prognosis (mortality) are not different from 'pure' COPD patients.<br /> (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Aged
Asthma drug therapy
Asthma epidemiology
Cohort Studies
Comorbidity
Diagnosis, Differential
Disease Progression
Female
France
Humans
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive epidemiology
Quality of Life
Risk Factors
Surveys and Questionnaires
Symptom Assessment
Syndrome
Asthma complications
Asthma diagnosis
Phenotype
Pulmonary Disease, Chronic Obstructive complications
Pulmonary Disease, Chronic Obstructive diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1398-9995
- Volume :
- 72
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 27501862
- Full Text :
- https://doi.org/10.1111/all.13004