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3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.

Authors :
Yadav VR
Prasad S
Gupta SC
Sung B
Phatak SS
Zhang S
Aggarwal BB
Source :
The Journal of biological chemistry [J Biol Chem] 2016 Aug 05; Vol. 291 (32), pp. 16926.
Publication Year :
2016

Details

Language :
English
ISSN :
1083-351X
Volume :
291
Issue :
32
Database :
MEDLINE
Journal :
The Journal of biological chemistry
Publication Type :
Academic Journal
Accession number :
27496967
Full Text :
https://doi.org/10.1074/jbc.A111.274613