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Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2016 Sep 25; Vol. 511 (2), pp. 814-20. Date of Electronic Publication: 2016 Aug 01. - Publication Year :
- 2016
-
Abstract
- Films composed of poly(ethylene carbonate) (PEC), a biodegradable polymer, were compared with poly(lactide-co-glycolide) (PLGA) films loaded with and without the tuberculosis drug rifampicin to study the characteristics and performance of PEC as a potential carrier for controlled drug delivery to macrophages. All drug-loaded PLGA and PEC films were amorphous indicating good miscibility of the drug in the polymers, even at high drug loading (up to 50wt.%). Polymer degradation studies showed that PLGA degraded slowly via bulk erosion while PEC degraded more rapidly and near-linearly via enzyme mediated surface erosion (by cholesterol esterase). Drug release studies performed with polymer films indicated a diffusion/erosion dependent delivery behavior for PLGA while an almost zero-order drug release profile was observed from PEC due to the controlled polymer degradation process. When exposed to polymer degradation products the murine macrophage cell line J774A.1 showed less susceptibility to PEC than to PLGA. However, when seeding the macrophages on PLGA and PEC films no relevant difference in cell proliferation/growth kinetics was observed. Overall, this study emphasizes that PEC is an attractive polymer for controlled drug release and could provide superior performance to PLGA for some drug delivery applications including the treatment of macrophage infections.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Proliferation drug effects
Cell Survival drug effects
Cells, Cultured
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Delayed-Action Preparations pharmacology
Drug Carriers chemistry
Drug Carriers pharmacokinetics
Drug Carriers pharmacology
Drug Liberation
Drug Stability
Macrophages drug effects
Polyglactin 910 chemistry
Rifampin chemistry
Polyethylenes chemistry
Rifampin pharmacokinetics
Rifampin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 511
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 27492019
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2016.07.075