Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis.

Authors :: Lee YH
Choi SJ
Ji JD
Song GG
Source :: Pharmacogenomics [Pharmacogenomics] 2016 Aug; Vol. 17 (13), pp. 1465-77. Date of Electronic Publication: 2016 Aug 04.
Publication Year :: 2016
Abstract: Aim: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.<br />Materials & Methods: We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to TNF blockers.<br />Results: The meta-analysis indicated that responsiveness to TNF blockers was associated with the FCGR3A V allele (odds ratio: 3.308; 95% CI: 1.053-10.39; p = 0.040) and the FCGR2A RR + RH genotype (odds ratio: 3.904; p = 0.027) in patients with a follow-up time of ≥6 months.<br />Conclusion: FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-α therapy in patients with follow-up times ≥6 months.

Subjects :: Genetic Variation genetics
Humans
Polymorphism, Genetic genetics
Crohn Disease drug therapy
Crohn Disease genetics
Psoriasis drug therapy
Psoriasis genetics
Receptors, IgG genetics
Spondylarthropathies drug therapy
Spondylarthropathies genetics
Tumor Necrosis Factor-alpha antagonists & inhibitors

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