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Cytomegalovirus disease in inflammatory bowel disease: epidemiology and disease characteristics in a large single-centre experience.
- Source :
-
European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2016 Nov; Vol. 28 (11), pp. 1329-34. - Publication Year :
- 2016
-
Abstract
- Background: Patients with inflammatory bowel disease (IBD) show an increased risk of developing cytomegalovirus (CMV) disease because of immunosuppressive medication and malnutrition. Here, we aimed to investigate the prevalence and clinical characteristics of CMV disease in our cohort of IBD patients.<br />Patients and Methods: We carried out a retrospective analysis of 1023 IBD patients treated at our IBD clinic at the University Hospital Zurich between 2007 and 2014. CMV disease was defined as a positive immunohistochemistry for CMV and 14 patients were identified.<br />Results: The prevalence of CMV disease in our IBD cohort was 1.37%. Twelve patients had ulcerative colitis and two had Crohn's disease with colonic involvement. All patients who developed CMV disease received immunosuppressive medication or, as in one case, had HIV infection. The most used immunosuppressive medications were steroids and azathioprine. The most common therapeutic strategy was the consecutive use of ganciclovir and valganciclovir. Ten patients recovered and two were treatment refractory; among these, one required colectomy and two had a relapse.<br />Conclusion: CMV disease may influence the clinical course of IBD. There is probably an association between CMV disease and IBD-specific medication. Risk factors, epidemiology and therapeutic strategy need to be further investigated.
- Subjects :
- Adult
Antiviral Agents therapeutic use
Cytomegalovirus Infections diagnosis
Cytomegalovirus Infections drug therapy
Cytomegalovirus Infections epidemiology
Cytomegalovirus Infections immunology
Female
Gastrointestinal Agents therapeutic use
Humans
Immunocompromised Host
Immunosuppressive Agents therapeutic use
Inflammatory Bowel Diseases drug therapy
Inflammatory Bowel Diseases epidemiology
Inflammatory Bowel Diseases immunology
Male
Opportunistic Infections diagnosis
Opportunistic Infections drug therapy
Opportunistic Infections epidemiology
Opportunistic Infections immunology
Prevalence
Recurrence
Retrospective Studies
Treatment Outcome
Cytomegalovirus Infections complications
Inflammatory Bowel Diseases complications
Opportunistic Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5687
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 27482785
- Full Text :
- https://doi.org/10.1097/MEG.0000000000000716