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Rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) in the management of primary mediastinal B-cell lymphoma: a subgroup analysis of the UK NCRI R-CHOP 14 versus 21 trial.
- Source :
-
British journal of haematology [Br J Haematol] 2016 Nov; Vol. 175 (4), pp. 668-672. Date of Electronic Publication: 2016 Aug 01. - Publication Year :
- 2016
-
Abstract
- We performed a subgroup analysis of the phase III UK National Cancer Research Institute R-CHOP-14 versus R-CHOP-21 (two- versus three-weekly rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) trial to evaluate the outcomes for 50 patients with World Health Organization 2008 classified primary mediastinal B-cell lymphoma identified from the trial database. At a median follow-up of 7·2 years the 5-year progression-free survival and overall survival was 79·8% and 83·8%, respectively. An exploratory analysis raised the possibility of a better outcome in those who received R-CHOP-14 and time intensification may still, in the rituximab era, merit testing in a randomised trial in this subgroup of patients.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Antibodies, Monoclonal, Murine-Derived therapeutic use
Clinical Trials, Phase III as Topic
Cyclophosphamide therapeutic use
Doxorubicin therapeutic use
Female
Humans
Lymphoma, B-Cell diagnosis
Lymphoma, B-Cell mortality
Male
Mediastinal Neoplasms diagnosis
Mediastinal Neoplasms mortality
Middle Aged
Multimodal Imaging
Neoplasm Staging
Prednisone therapeutic use
Prognosis
Proportional Hazards Models
Rituximab
Treatment Outcome
Tumor Burden
Vincristine therapeutic use
Young Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Lymphoma, B-Cell drug therapy
Mediastinal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 175
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 27477167
- Full Text :
- https://doi.org/10.1111/bjh.14287