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The latex sap of the 'Old World Plant' Lagenaria siceraria with potent lectin activity mitigates neoplastic malignancy targeting neovasculature and cell death.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2016 Oct; Vol. 39, pp. 158-171. Date of Electronic Publication: 2016 Jul 29. - Publication Year :
- 2016
-
Abstract
- Lifestyle and dietary modifications have contributed much to somatic genetic alteration which has concomitantly led to increase in malignant diseases. Henceforth, plant based and dietary interventions to mitigate and impede oncogenic transformation are in great demand. We investigated the latex sap (LSL) of the dietary Lagenaria siceraria vegetable, the first domesticated plant species with the potent lectin activity for its functional role against the tumor progression and its mechanism. LSL has markedly stimulated proliferation of lymphocytes and displayed strong cytotoxic activity against cancer both in-vitro and in-vivo. The tumor regression was paralleled with drastic reduction in tumoral neovasculature as evidenced from angiogenic parameters and abrogated related gene expressions. LSL has also triggered apoptotic signaling cascade in cancer cells through activation of caspase-3 mediated activation of endonuclease and inducing apoptotic cellular events. Collectively our study provides tangible evidences that latex sap from L. siceraria with immunopotentiating ability significantly regresses the tumor progression by targeting angiogenesis and inducing cell death.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Aorta physiology
Apoptosis drug effects
Cell Proliferation drug effects
Female
Gene Expression Regulation, Neoplastic drug effects
Humans
Lymphocytes physiology
MCF-7 Cells
Mice
NIH 3T3 Cells
Neoplasm Transplantation
Organ Culture Techniques
Rats
Tumor Burden drug effects
Aorta drug effects
Cucurbitaceae immunology
Latex therapeutic use
Lymphocytes drug effects
Neoplasms drug therapy
Neovascularization, Pathologic drug therapy
Plant Lectins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 39
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 27475665
- Full Text :
- https://doi.org/10.1016/j.intimp.2016.07.024