Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.

Authors :: Mandal PK
Baptiste B
Langlois d'Estaintot B
Kauffmann B
Huc I
Source :: Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Oct 17; Vol. 17 (20), pp. 1911-1914. Date of Electronic Publication: 2016 Aug 19.
Publication Year :: 2016
Abstract: Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G <subscript>4</subscript> T <subscript>4</subscript> G <subscript>4</subscript> ) <subscript>2</subscript> with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G <subscript>4</subscript> T <subscript>4</subscript> G <subscript>4</subscript> ) <subscript>2</subscript> in the solid state are observed.<br /> (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Crystallography, X-Ray
Ligands
Models, Molecular
Molecular Conformation
Oxytricha chemistry
Amides chemistry
DNA, Protozoan chemistry
G-Quadruplexes
Quinolines chemistry

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