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Glycyrrhizic acid prevents astrocyte death by neuromyelitis optica-specific IgG via inhibition of C1q binding.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Sep 16; Vol. 478 (2), pp. 553-8. Date of Electronic Publication: 2016 Jul 25. - Publication Year :
- 2016
-
Abstract
- Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pathway. We aimed to study the influence of GA on NMO-IgG-induced CDC. NMO-IgG samples from 7 patients with NMO, together with human complement, induced CDC in an aquaporin 4 M23-overexpressing glial cell line, an in vitro NMO model. GA attenuated NMO-IgG-induced CDC in a dose-dependent manner. The mechanism of the GA-related CDC inhibition was sequentially dissected and found to involve inhibition of C1q binding to NMO-IgG. Consequently, GA attenuates NMO-IgG-induced CDC and may be a promising novel therapeutic agent against NMO.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Astrocytes immunology
Astrocytes pathology
Cell Death drug effects
Cell Line, Tumor
Female
Glycyrrhizic Acid therapeutic use
Humans
Immunoglobulin G immunology
Immunologic Factors therapeutic use
Male
Middle Aged
Neuromyelitis Optica immunology
Neuromyelitis Optica pathology
Neuroprotective Agents therapeutic use
Astrocytes drug effects
Complement C1q immunology
Cytotoxicity, Immunologic drug effects
Glycyrrhizic Acid pharmacology
Immunologic Factors pharmacology
Neuromyelitis Optica drug therapy
Neuroprotective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 478
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27462020
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.07.098