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HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.
- Source :
-
EBioMedicine [EBioMedicine] 2016 Sep; Vol. 11, pp. 68-72. Date of Electronic Publication: 2016 Jul 20. - Publication Year :
- 2016
-
Abstract
- HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM-) stage, that is ≤2weeks from infection. Without antiretroviral therapy (ART), HIV DNA peaked at 2weeks after enrollment, reaching a set-point 2weeks later with little change thereafter. There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2weeks and 316-fold after 3years. Therefore, very early ART offers the opportunity to significantly reduce the frequency of cells harboring HIV DNA.<br /> (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Anti-HIV Agents pharmacology
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Female
Genotype
HIV Infections diagnosis
HIV-1 classification
Humans
Leukocytes, Mononuclear virology
Male
RNA, Viral
Viral Load
Young Adult
Anti-HIV Agents therapeutic use
DNA, Viral
HIV Infections drug therapy
HIV Infections virology
HIV-1 physiology
Proviruses
Subjects
Details
- Language :
- English
- ISSN :
- 2352-3964
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- EBioMedicine
- Publication Type :
- Academic Journal
- Accession number :
- 27460436
- Full Text :
- https://doi.org/10.1016/j.ebiom.2016.07.024