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Recombinant human granulocyte macrophage colony stimulating factor (hGM-CSF): Possibility of nanoparticle-mediated delivery in cancer immunotherapy.
- Source :
-
Bioengineered [Bioengineered] 2017 Mar 04; Vol. 8 (2), pp. 120-123. Date of Electronic Publication: 2016 Jul 26. - Publication Year :
- 2017
-
Abstract
- Most of the cancer treatment strategies from chemotherapy to radiotherapy render cancer cells apoptotic and these apoptotic cancer cells accumulate at the tumor sites. The accumulation of apoptotic cancer cells often result in inflammation and autoimmune responses causing serious health implications. Macrophages, which are effective immune combatants, can help in the clearance of these deleterious occupants. Granulocyte macrophage colony stimulating factor (GM-CSF) is a key cytokine, modulator of immune system and responsible for growth and differentiation of granulocytes and macrophages. In this regard, supply of recombinant GM-CSF can enhance the capability of macrophages for clearance of apoptotic cancer cells. However, delivery of the cytokine in vivo can suffer from certain disadvantages like faster depletion, less stability and low targeting efficiency. We believe that the stability and sustained release of GM-CSF can be improved through its encapsulation inside appropriately designed nanoparticles.
- Subjects :
- Apoptosis drug effects
Granulocyte-Macrophage Colony-Stimulating Factor pharmacology
Humans
Macrophages metabolism
Recombinant Proteins administration & dosage
Recombinant Proteins chemistry
Recombinant Proteins pharmacology
Granulocyte-Macrophage Colony-Stimulating Factor administration & dosage
Granulocyte-Macrophage Colony-Stimulating Factor chemistry
Immunotherapy
Nanoparticles administration & dosage
Nanoparticles chemistry
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2165-5987
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioengineered
- Publication Type :
- Academic Journal
- Accession number :
- 27459024
- Full Text :
- https://doi.org/10.1080/21655979.2016.1212136