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Synthesis and evaluation of multi-wall carbon nanotube-paclitaxel complex as an anti-cancer agent.

Authors :
Ghasemvand F
Biazar E
Tavakolifard S
Khaledian M
Rahmanzadeh S
Momenzadeh D
Afroosheh R
Zarkalami F
Shabannezhad M
Hesami Tackallou S
Massoudi N
Heidari Keshel S
Source :
Gastroenterology and hepatology from bed to bench [Gastroenterol Hepatol Bed Bench] 2016 Summer; Vol. 9 (3), pp. 197-204.
Publication Year :
2016

Abstract

Aim: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer.<br />Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading.<br />Patients and Methods: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses.<br />Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line.<br />Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport.

Details

Language :
English
ISSN :
2008-2258
Volume :
9
Issue :
3
Database :
MEDLINE
Journal :
Gastroenterology and hepatology from bed to bench
Publication Type :
Academic Journal
Accession number :
27458512