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Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial.
- Source :
-
The Veterinary record [Vet Rec] 2016 Sep 24; Vol. 179 (12), pp. 308. Date of Electronic Publication: 2016 Jul 22. - Publication Year :
- 2016
-
Abstract
- The aim of this study was to evaluate the clinical success of whole-flock systemic tilmicosin and enhanced biosecurity in eliminating active contagious ovine digital dermatitis (CODD) from sheep flocks. Thirty flocks in the UK were randomly allocated to receive either treatment as usual (as per the farmer's normal routine) or whole-flock treatment with tilmicosin, together with isolation and extended treatment of clinically affected individuals and isolation and treatment of purchased sheep during the study period. All flocks were visited once at onset of the trial to examine all sheep. One year later, all sheep were re-examined to determine the presence/absence of clinical lesions. The primary outcome was the clinical elimination of CODD from flocks. Secondary outcomes were reduction in prevalence of CODD, clinical elimination of footrot and reduction in prevalence of footrot. The analysis included 11 control flocks and 13 intervention flocks, with initially 3460 and 4686 sheep, respectively. For CODD: at follow-up, in the intervention group, 6/13 (46 per cent) flocks had a prevalence of zero compared with 1/11 (9 per cent) in the control group (P=0.12). For footrot: at follow-up, no flocks had a prevalence of zero. Therefore, the intervention is not recommended for the elimination of CODD or footrot in the UK.<br /> (British Veterinary Association.)
- Subjects :
- Animals
Cluster Analysis
Digital Dermatitis epidemiology
Foot Rot epidemiology
Sheep
Sheep Diseases epidemiology
Treatment Outcome
Tylosin therapeutic use
United Kingdom epidemiology
Anti-Bacterial Agents therapeutic use
Digital Dermatitis drug therapy
Foot Rot drug therapy
Sheep Diseases drug therapy
Tylosin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 2042-7670
- Volume :
- 179
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Veterinary record
- Publication Type :
- Academic Journal
- Accession number :
- 27450091
- Full Text :
- https://doi.org/10.1136/vr.103625