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Experimental renal papillary necrosis in the Syrian hamster.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1989 May; Vol. 27 (5), pp. 331-40. - Publication Year :
- 1989
-
Abstract
- These studies evaluate the susceptibility of the Syrian hamster to the induction of renal papillary lesions after exposure to 2-bromethylamine (2-BEA), mefenamic acid, indomethacin, acetaminophen and phenylbutazone. In most cases there were 25 animals per dose group. Papillary necrosis was produced by single or multiple ip doses of 75 mg 2-BEA/kg and above, and was present within 12 hr of administration of a dose of 500 mg/kg body weight. There were lesions in the renal papilla of hamsters 10 days after a single dose of 500 mg 2-BEA/kg. The severity of papillary lesions increased up to 4 days after exposure in hamsters given a single dose of either 250 or 500 mg 2-BEA/kg. The severity of papillary lesions did not increase with the number of doses in hamsters given multiple doses (2-5) of 100 mg 2-BEA/kg. Renal papillary necrosis was observed in about 40% of hamsters given 100, 200 or 400 mg mefenamic acid/kg. Only a few of the hamsters given indomethacin had renal papillary lesions and none of those given acetaminophen (up to 400 mg/kg) or phenylbutazone (up to 600 mg/kg) developed renal papillary lesions.
- Subjects :
- Acetaminophen toxicity
Animals
Ethylamines toxicity
Indomethacin toxicity
Kidney Medulla pathology
Kidney Papillary Necrosis pathology
Male
Mefenamic Acid toxicity
Phenylbutazone toxicity
Cricetinae
Disease Models, Animal
Kidney Medulla drug effects
Kidney Papillary Necrosis chemically induced
Mesocricetus
Subjects
Details
- Language :
- English
- ISSN :
- 0278-6915
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 2744664
- Full Text :
- https://doi.org/10.1016/0278-6915(89)90136-1