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Reduced cardiac autonomic response to deep breathing: A heritable vulnerability trait in patients with schizophrenia and their healthy first-degree relatives.
- Source :
-
Psychiatry research [Psychiatry Res] 2016 Sep 30; Vol. 243, pp. 335-41. Date of Electronic Publication: 2016 Jul 01. - Publication Year :
- 2016
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Abstract
- Reduced resting heart rate variability (HRV) has been observed in patients with schizophrenia and their relatives, suggesting genetic predispositions. However, findings have not been consistent. We assessed cardiac autonomic response to deep breathing in first-degree relatives of patients with schizophrenia (n=45; 26 female; aged 39.69±14.82 years). Data were compared to healthy controls (n=45; 26 female; aged 38.27±9.79 years) matched for age, gender, body mass index and physical activity as well as to unmedicated patients with acute schizophrenia (n=45; 25 female; aged 37.31±12.65 years). Electrocardiograms were recorded under supine resting and deep-breathing conditions (10-12breaths/min). We measured HRV components including variance, low-frequency (LF) power, which may reflect baroreflex function, high-frequency (HF) power, which reflects cardiac parasympathetic activity, and LF/HF ratio, which may reflect sympatho-vagal balance. Patients rather than relatives exhibited lower resting-state HRV (variance, LF, and HF) than controls. As expected, deep breathing induced an increase in variance and HF-HRV in controls. However, such a response was significantly reduced in both patients and their relatives. In conclusion, the diminished cardiac autonomic reactivity to deep breathing seen in patients and their unaffected relatives indicates that this pattern of cardiac autonomic dysregulation may be regarded as a genetic trait marker for schizophrenia.<br /> (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Autonomic Nervous System physiopathology
Electrocardiography trends
Female
Genetic Predisposition to Disease epidemiology
Humans
Male
Middle Aged
Schizophrenia diagnosis
Blood Pressure physiology
Genetic Predisposition to Disease genetics
Heart Rate physiology
Quantitative Trait, Heritable
Respiration genetics
Schizophrenia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 243
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 27442977
- Full Text :
- https://doi.org/10.1016/j.psychres.2016.04.076