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Stem Cell-Based Therapies for Ischemic Stroke: Preclinical Results and the Potential of Imaging-Assisted Evaluation of Donor Cell Fate and Mechanisms of Brain Regeneration.
- Source :
-
Medicinal research reviews [Med Res Rev] 2016 Nov; Vol. 36 (6), pp. 1080-1126. Date of Electronic Publication: 2016 Jul 21. - Publication Year :
- 2016
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Abstract
- Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed.<br /> (© 2016 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Brain Ischemia diagnostic imaging
Brain Ischemia pathology
Humans
Induced Pluripotent Stem Cells transplantation
Luminescent Measurements methods
Magnetic Resonance Imaging methods
Mesenchymal Stem Cell Transplantation methods
Positron-Emission Tomography methods
Regeneration physiology
Stroke diagnostic imaging
Stroke pathology
Tomography, Emission-Computed, Single-Photon methods
Brain Ischemia therapy
Stem Cell Transplantation methods
Stroke therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1098-1128
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medicinal research reviews
- Publication Type :
- Academic Journal
- Accession number :
- 27439773
- Full Text :
- https://doi.org/10.1002/med.21400