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A post hoc analysis of long-term prognosis after exenatide treatment in patients with ST-segment elevation myocardial infarction.
- Source :
-
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2016 Jul 20; Vol. 12 (4), pp. 449-55. - Publication Year :
- 2016
-
Abstract
- Aims: We aimed to assess the effect of exenatide treatment as an adjunct to primary percutaneous coronary intervention (PCI) on long-term clinical outcome.<br />Methods and Results: We performed a post hoc analysis in 334 patients with a first STEMI included in a previous study randomised to exenatide (n=175) or placebo (n=159) as an adjunct to primary PCI. The primary endpoint was a composite of all-cause mortality and admission for heart failure during a median follow-up of 5.2 years (interquartile range: 5.0-5.5). Secondary endpoints were all-cause mortality and admission for heart failure, individually. The primary composite endpoint occurred in 24% in the exenatide group versus 27% in the placebo group, p=0.44 (HR 0.80, p=0.35). Admission for heart failure was lower in the exenatide (11%) compared to the placebo group (20%) (HR 0.53, p=0.042). All-cause mortality occurred in 14% in the exenatide group versus 9% in the placebo group (HR 1.45, p=0.20).<br />Conclusions: In this post hoc analysis of patients with a STEMI, treatment with exenatide at the time of primary PCI did not reduce the primary composite endpoint or the secondary endpoint of all-cause -mortality. However, exenatide treatment reduced the incidence of admission for heart failure.
- Subjects :
- Adult
Aged
Aged, 80 and over
Electrocardiography methods
Exenatide
Female
Heart Failure epidemiology
Heart Failure therapy
Humans
Male
Middle Aged
Prognosis
Treatment Outcome
Myocardial Infarction epidemiology
Myocardial Infarction therapy
Peptides therapeutic use
Percutaneous Coronary Intervention methods
Platelet Aggregation Inhibitors therapeutic use
Venoms therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1969-6213
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 27436599
- Full Text :
- https://doi.org/10.4244/EIJV12I4A78