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Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease.
- Source :
-
Renal failure [Ren Fail] 2016 Sep; Vol. 38 (8), pp. 1267-75. Date of Electronic Publication: 2016 Jul 19. - Publication Year :
- 2016
-
Abstract
- Glomerular filtration rate and/or creatinine are not accurate methods for renal failure prediction. This study tested homocysteine (Hcy) as a predictive and prognostic marker for end stage renal disease (ESRD). In total, 176 subjects were recruited and divided into: healthy normal group (108 subjects); mild-to-moderate impaired renal function group (21 patients); severe impaired renal function group (7 patients); and chronic renal failure group (40 patients) who were on regular hemodialysis. Blood samples were collected, and serum was separated for analysis of total Hcy, creatinine, high sensitive C-reactive protein (CRP), serum albumin, and calcium. Data showed that Hcy level was significantly increased from normal-to-mild impairment then significantly decreases from mild impairment until the patient reaches severe impairment while showing significant elevation in the last stage of chronic renal disease. Creatinine level was increased in all stages of kidney impairment in comparison with control. CRP level was showing significant elevation in the last stage. A significant decrease in both albumin and calcium was occurred in all stages of renal impairment. We conclude Hcy in combination with CRP, creatinine, albumin, and calcium can be used as a prognostic marker for ESRD and an early diagnostic marker for the risk of renal failure.
- Subjects :
- Adult
Biomarkers blood
Calcium blood
Case-Control Studies
Egypt
Female
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic diagnosis
Kidney Failure, Chronic therapy
Male
Middle Aged
Multivariate Analysis
Renal Dialysis
Serum Albumin
C-Reactive Protein analysis
Creatinine blood
Disease Progression
Early Diagnosis
Homocysteine blood
Kidney Failure, Chronic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1525-6049
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Renal failure
- Publication Type :
- Academic Journal
- Accession number :
- 27435113
- Full Text :
- https://doi.org/10.1080/0886022X.2016.1209382