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Studies on gastric antiulcer active agents. II. Synthesis of tetrazole alkanamides and related compounds.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1989 Feb; Vol. 37 (2), pp. 322-6. - Publication Year :
- 1989
-
Abstract
- A series of tetrazole alkanamides was synthesized and tested for antiulcer activity against acetic acid-induced gastric ulcer in rats. These compounds were prepared by the reaction of tetrazole alkanoic acids and various amines by the mixed anhydride method or acid chloride method. Among them, 3-[(1-ethyl-5-tetrazolyl)methylthio]propionamide (IIn) was found to have the most potent activity. The structure-activity relationships are discussed.
Details
- Language :
- English
- ISSN :
- 0009-2363
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 2743478
- Full Text :
- https://doi.org/10.1248/cpb.37.322