Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues.

Authors :: Bouin A
Nguyen Y
Wehbe M
Renois F
Fornes P
Bani-Sadr F
Metz D
Andreoletti L
Source :: Emerging infectious diseases [Emerg Infect Dis] 2016 Aug; Vol. 22 (8), pp. 1488-90.
Publication Year :: 2016
Abstract: We performed deep sequencing analysis of the enterovirus 5' noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8.

Subjects :: Coxsackievirus Infections pathology
DNA Mutational Analysis
Female
Humans
Middle Aged
RNA, Viral
Sequence Deletion
Coxsackievirus Infections virology
Endocarditis virology
Enterovirus B, Human genetics
Heart virology
Myocardium pathology

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