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Default mode network coherence in treatment-resistant major depressive disorder during electroconvulsive therapy.
- Source :
-
Journal of affective disorders [J Affect Disord] 2016 Nov 15; Vol. 205, pp. 130-137. Date of Electronic Publication: 2016 Jun 27. - Publication Year :
- 2016
-
Abstract
- Background: Functional connectivity in the "default mode network" (DMN) is changed in depression, and evidence suggests depression also affects the DMN's spatial topography and might cause a dissociation between its anterior and posterior regions. As antidepressive treatment affects anterior and posterior regions of the network differently, how depression and treatment change DMN-organization is crucial for understanding their mechanisms. We present a novel way of assessing the coherence of a network's regions to the network as a whole, and apply this to investigate treatment-resistant depression and the effects of electroconvulsive therapy (ECT).<br />Methods: Resting-state functional MRI was collected from 16 patients with treatment-resistant depression before and after ECT and 16 healthy controls matched for age and sex. For each subject, the mean time series of the DMN was used as a regressor for each voxel within the DMN, creating a map of "network coherence" (NC). The obtained maps were compared across groups using permutation testing.<br />Results: NC was significantly decreased in depressed subjects in the precuneus and the angular gyrus. With ECT the NC normalized in responders (n=8), but not in non-responders (n=8).<br />Conclusions: We present a novel method of investigating within-network coherence and apply this to show that in depression, a large area of the DMN shows a decrease in coherence to the network as a whole. Although tentative due to the small sample size, we find that this effect is not present after ECT in those improving clinically, but persists in patients not responding to ECT.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Antidepressive Agents therapeutic use
Case-Control Studies
Female
Humans
Magnetic Resonance Imaging methods
Male
Middle Aged
Brain physiopathology
Depressive Disorder, Major physiopathology
Depressive Disorder, Major therapy
Depressive Disorder, Treatment-Resistant physiopathology
Depressive Disorder, Treatment-Resistant therapy
Electroconvulsive Therapy
Nerve Net physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 205
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 27434117
- Full Text :
- https://doi.org/10.1016/j.jad.2016.06.059